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Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding
Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins. The method presented here describes the criticality assessment of therapeutic antibody modifications by size-exclusion chromatography (SEC) o...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899689/ https://www.ncbi.nlm.nih.gov/pubmed/33616001 http://dx.doi.org/10.1080/19420862.2021.1887612 |