Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

Therapeutic proteins including antibodies and Fc-fusion proteins undergo a large number of chemical modifications during cell culture, purification, storage and in human circulation. They are also exposed to harsh conditions during stress studies, including elevated temperature, extremes of pH, forc...

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Detalles Bibliográficos
Autores principales: Bondarenko, Pavel, Nichols, Andrew C., Xiao, Gang, Shi, Rachel Liuqing, Chan, Pik Kay, Dillon, Thomas M, Garces, Fernando, Semin, David J., Ricci, Margaret S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899697/
https://www.ncbi.nlm.nih.gov/pubmed/33615991
http://dx.doi.org/10.1080/19420862.2021.1887629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899697/
https://www.ncbi.nlm.nih.gov/pubmed/33615991
http://dx.doi.org/10.1080/19420862.2021.1887629

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