SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis

Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and features of plaque instability, in part, through lipid-mediated oxidative DNA damage and telomere dysfunction. SIRT6 (Sirtuin 6) is a nuclear deacetylase involved in DNA damage response signaling, inflammation, and metabolism...

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Detalles Bibliográficos
Autores principales: Grootaert, Mandy O.J., Finigan, Alison, Figg, Nichola L., Uryga, Anna K., Bennett, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899748/
https://www.ncbi.nlm.nih.gov/pubmed/33353368
http://dx.doi.org/10.1161/CIRCRESAHA.120.318353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899748/
https://www.ncbi.nlm.nih.gov/pubmed/33353368
http://dx.doi.org/10.1161/CIRCRESAHA.120.318353

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