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SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis

Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and features of plaque instability, in part, through lipid-mediated oxidative DNA damage and telomere dysfunction. SIRT6 (Sirtuin 6) is a nuclear deacetylase involved in DNA damage response signaling, inflammation, and metabolism...

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Detalles Bibliográficos
Autores principales:	Grootaert, Mandy O.J., Finigan, Alison, Figg, Nichola L., Uryga, Anna K., Bennett, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899748/ https://www.ncbi.nlm.nih.gov/pubmed/33353368 http://dx.doi.org/10.1161/CIRCRESAHA.120.318353

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