Longitudinal and multi-tissue molecular diagnostics track somatic BRCA2 reversion mutations that correct the open reading frame of germline alteration upon clinical relapse

BRCA-mutant cancers often develop therapeutic resistance through several mechanisms. Here, we report a case of pathogenic germline BRCA2-driven breast cancer monitored for disease progression and acquired resistance using longitudinal multi-tissue genomic testing. Briefly, genomic testing was perfor...

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Detalles Bibliográficos
Autores principales: Sorrells, Shelly, McKinnon, Kelly E., McBratney, Ashleigh, Sumey, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900170/
https://www.ncbi.nlm.nih.gov/pubmed/33619265
http://dx.doi.org/10.1038/s41525-021-00181-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900170/
https://www.ncbi.nlm.nih.gov/pubmed/33619265
http://dx.doi.org/10.1038/s41525-021-00181-0

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