RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

Attachment of ubiquitin (Ub) to proteins is one of the most abundant and versatile of all posttranslational modifications and affects outcomes in essentially all physiological processes. RING E3 ligases target E2 Ub-conjugating enzymes to the substrate, resulting in its ubiquitination. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiss, Leo, Clift, Dean, Renner, Nadine, Neuhaus, David, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900206/
https://www.ncbi.nlm.nih.gov/pubmed/33619271
http://dx.doi.org/10.1038/s41467-021-21443-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900206/
https://www.ncbi.nlm.nih.gov/pubmed/33619271
http://dx.doi.org/10.1038/s41467-021-21443-6

Ejemplares similares