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RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
Attachment of ubiquitin (Ub) to proteins is one of the most abundant and versatile of all posttranslational modifications and affects outcomes in essentially all physiological processes. RING E3 ligases target E2 Ub-conjugating enzymes to the substrate, resulting in its ubiquitination. However, the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900206/ https://www.ncbi.nlm.nih.gov/pubmed/33619271 http://dx.doi.org/10.1038/s41467-021-21443-6 |