Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Programmed death-ligand 1 is a glycoprotein expressed on antigen presenting cells, hepatocytes, and tumors which upon interaction with programmed death-1, results in inhibition of antigen-specific T cell responses. Here, we report a mechanism of inhibiting programmed death-ligand 1 through small mol...

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Detalles Bibliográficos
Autores principales: Park, Jang-June, Thi, Emily P., Carpio, Victor H., Bi, Yingzhi, Cole, Andrew G., Dorsey, Bruce D., Fan, Kristi, Harasym, Troy, Iott, Christina L., Kadhim, Salam, Kim, Jin Hyang, Lee, Amy C. H., Nguyen, Duyan, Paratala, Bhavna S., Qiu, Ruiqing, White, Andre, Lakshminarasimhan, Damodharan, Leo, Christopher, Suto, Robert K., Rijnbrand, Rene, Tang, Sunny, Sofia, Michael J., Moore, Chris B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900207/
https://www.ncbi.nlm.nih.gov/pubmed/33619272
http://dx.doi.org/10.1038/s41467-021-21410-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900207/
https://www.ncbi.nlm.nih.gov/pubmed/33619272
http://dx.doi.org/10.1038/s41467-021-21410-1

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