Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian regulation of epileptic seizures. We first show up-regulation of REV-ERBα/Rev-erbα in brain tissues from patients with epilepsy and a m...

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Detalles Bibliográficos
Autores principales: Zhang, Tianpeng, Yu, Fangjun, Xu, Haiman, Chen, Min, Chen, Xun, Guo, Lianxia, Zhou, Cui, Xu, Yuting, Wang, Fei, Yu, Jiandong, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900242/
https://www.ncbi.nlm.nih.gov/pubmed/33619249
http://dx.doi.org/10.1038/s41467-021-21477-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900242/
https://www.ncbi.nlm.nih.gov/pubmed/33619249
http://dx.doi.org/10.1038/s41467-021-21477-w

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