Cargando…

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian regulation of epileptic seizures. We first show up-regulation of REV-ERBα/Rev-erbα in brain tissues from patients with epilepsy and a m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Tianpeng, Yu, Fangjun, Xu, Haiman, Chen, Min, Chen, Xun, Guo, Lianxia, Zhou, Cui, Xu, Yuting, Wang, Fei, Yu, Jiandong, Wu, Baojian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900242/ https://www.ncbi.nlm.nih.gov/pubmed/33619249 http://dx.doi.org/10.1038/s41467-021-21477-w

Ejemplares similares

The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition
por: Yu, Fangjun, et al.
Publicado: (2019)

Rev-erb in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity
por: Ding, Guolian, et al.
Publicado: (2021)

Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding
por: Yu, Fangjun, et al.
Publicado: (2021)

Chronoeffects of the Herbal Medicines Puerariae radix and Coptidis rhizoma in Mice: A Potential Role of REV-ERBα
por: Liu, Jinming, et al.
Publicado: (2021)

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis
por: Wang, Shuai, et al.
Publicado: (2018)

Targeting REV-ERBα for therapeutic purposes: promises and challenges
por: Wang, Shuai, et al.
Publicado: (2020)

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity
por: Zhang, Tianpeng, et al.
Publicado: (2018)

Regulation of Circadian Behavior and Metabolism by Rev-erbα and Rev-erbβ
por: Cho, Han, et al.
Publicado: (2012)

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model
por: Yue, Jiong, et al.
Publicado: (2020)

REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output
por: Ikeda, Ryosuke, et al.
Publicado: (2019)

REV-ERB is essential in cardiac fibroblasts homeostasis
por: Luo, Xiaokang, et al.
Publicado: (2022)

Downregulation of REV-ERBα is associated with the progression of lung adenocarcinoma
por: Zhang, Hao, et al.
Publicado: (2022)

Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle
por: Amador, Ariadna, et al.
Publicado: (2018)

BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice
por: Li, Feng, et al.
Publicado: (2022)

Direct Regulation of CLOCK Expression by REV-ERB
por: Crumbley, Christine, et al.
Publicado: (2011)

Rev-erbs and Glia—Implications for Neurodegenerative Diseases
por: Griffin, Percy, et al.
Publicado: (2019)

The Role of REV-ERB Receptors in Cancer Pathogenesis
por: Gomatou, Georgia, et al.
Publicado: (2023)

Puerariae lobatae radix protects against UVB-induced skin aging via antagonism of REV-ERBα in mice
por: Ma, Luyao, et al.
Publicado: (2022)

Scutellaria baicalensis Georgi regulates REV-ERBα/BMAL1 to protect against skin aging in mice
por: Sun, Guanghui, et al.
Publicado: (2022)

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation
por: Amador, Ariadna, et al.
Publicado: (2016)

Expression of AFP and Rev-Erb A/Rev-Erb B and N-CoR in fetal rat liver, liver injury and liver regeneration
por: Meier, Volker, et al.
Publicado: (2006)

Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists
por: Solt, Laura A., et al.
Publicado: (2012)

Novel Function of Rev-erbα in Promoting Brown Adipogenesis
por: Nam, Deokhwa, et al.
Publicado: (2015)

Rev-erbα in the brain is essential for circadian food entrainment
por: Delezie, Julien, et al.
Publicado: (2016)

Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway
por: Sheng, Mingyue, et al.
Publicado: (2023)

Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice
por: Lin, Yanke, et al.
Publicado: (2019)

REV-ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer
por: Wang, Xiaoshan, et al.
Publicado: (2018)

The Nuclear Receptor Rev-erbα Controls Circadian Thermogenic Plasticity
por: Gerhart-Hines, Zachary, et al.
Publicado: (2013)

REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor
por: Okabe, Takashi, et al.
Publicado: (2016)

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene induced senescence
por: Sulli, Gabriele, et al.
Publicado: (2018)

The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis
por: Chatterjee, Somik, et al.
Publicado: (2019)

REV-ERBα Regulates T(H)17 Cell Development and Autoimmunity
por: Amir, Mohammed, et al.
Publicado: (2018)

Myocardial Rev-erb–Mediated Diurnal Metabolic Rhythm and Obesity Paradox
por: Song, Shiyang, et al.
Publicado: (2022)

Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB
por: Murray, Meghan H., et al.
Publicado: (2022)

Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis
por: Raza, Ghulam Shere, et al.
Publicado: (2022)

Epileptic seizures
por: Anwar, Haleema, et al.
Publicado: (2020)

Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy
por: Liu, Qingxue, et al.
Publicado: (2021)

Posttranslational Modifications of Rev-Erbα Protein and Abnormal Inflammatory Response in Gastric Cancer
por: Ke, Chen, et al.
Publicado: (2022)

Helicobacter pylori–Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense
por: Mao, Fang-Yuan, et al.
Publicado: (2021)

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
por: Le Martelot, Gwendal, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_kaj74dp07plk837p6gnrqa860d