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Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter
Proper targeting of the urate and xenobiotic transporter ATP-binding transporter subfamily G member 2 (ABCG2) to the plasma membrane (PM) is essential for its normal function. The naturally occurring Q141K and M71V polymorphisms in ABCG2, associated with gout and hyperuricemia, affect the cellular r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900420/ https://www.ncbi.nlm.nih.gov/pubmed/33634118 http://dx.doi.org/10.3389/fcell.2021.615729 |