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Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4

[Image: see text] Herein, we report the stereoselective and convergent synthesis of resolvin E4, a newly identified specialized pro-resolving mediator. This synthesis proves the absolute configuration and exact olefin geometry. Key elements of the successful strategy include a highly stereoselective...

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Detalles Bibliográficos
Autores principales: Reinertsen, Amalie Føreid, Primdahl, Karoline Gangestad, Shay, Ashley Elizabeth, Serhan, Charles Nicholas, Hansen, Trond Vidar, Aursnes, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901022/
https://www.ncbi.nlm.nih.gov/pubmed/33534565
http://dx.doi.org/10.1021/acs.joc.0c02913