Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-approved and novel therapeutics targeting the viral proteome, highlighting the urgent need for efficient drug discovery strategies. Even with effective vaccines, infection is possible, and at-risk populations would...

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Detalles Bibliográficos
Autores principales: Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901392/
https://www.ncbi.nlm.nih.gov/pubmed/33636189
http://dx.doi.org/10.1016/j.pbiomolbio.2021.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901392/
https://www.ncbi.nlm.nih.gov/pubmed/33636189
http://dx.doi.org/10.1016/j.pbiomolbio.2021.02.002

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