Cargando…

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-approved and novel therapeutics targeting the viral proteome, highlighting the urgent need for efficient drug discovery strategies. Even with effective vaccines, infection is possible, and at-risk populations would...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901392/ https://www.ncbi.nlm.nih.gov/pubmed/33636189 http://dx.doi.org/10.1016/j.pbiomolbio.2021.02.002

Ejemplares similares

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
por: Houl, Jerry H., et al.
Publicado: (2019)

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
por: Moiani, Davide, et al.
Publicado: (2021)

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells
por: James, Dominic I., et al.
Publicado: (2016)

Poly(ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Benzo(a)pyrene Induced Cell Transformation
por: Li, Xuan, et al.
Publicado: (2016)

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
por: Barkauskaite, Eva, et al.
Publicado: (2013)

Crystal structure of (E)-13-(pyrimidin-5-yl)parthenolide
por: Bommagani, Shobanbabu, et al.
Publicado: (2015)

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication
por: Tsutakawa, Susan E., et al.
Publicado: (2021)

Crystal structure of 13-(E)-(2-aminobenzylidene)parthenolide
por: Bommagani, Shobanbabu, et al.
Publicado: (2018)

Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology
por: Brosey, Chris A, et al.
Publicado: (2019)

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2020)

Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a unique substrate-binding element
por: Kim, In-Kwon, et al.
Publicado: (2012)

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
por: Slade, Dea, et al.
Publicado: (2011)

Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure
por: Koludarov, Ivan, et al.
Publicado: (2019)

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
por: Harrision, Daniel, et al.
Publicado: (2020)

Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl}parthenolide methanol hemisolvate
por: Penthala, Narsimha Reddy, et al.
Publicado: (2014)

Crystal structure of 4,5-bis(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole methanol monosolvate
por: Madadi, Nikhil Reddy, et al.
Publicado: (2014)

Structure of the sirtuin‐linked macrodomain SAV0325 from Staphylococcus aureus
por: Appel, C. Denise, et al.
Publicado: (2016)

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response
por: Wilson, David M., et al.
Publicado: (2020)

Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure
por: Dai, Wenjuan, et al.
Publicado: (2019)

GRB2 enforces homology-directed repair initiation by MRE11
por: Ye, Zu, et al.
Publicado: (2021)

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease
por: Lees-Miller, James P., et al.
Publicado: (2020)

Comparison of crystal structures of 4-(benzo[b]thiophen-2-yl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole and 4-(benzo[b]thiophen-2-yl)-2-methyl-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole
por: Penthala, Narsimha Reddy, et al.
Publicado: (2014)

A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain
por: Anmangandla, Ananya, et al.
Publicado: (2023)

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain
por: Sherrill, Lavinia M., et al.
Publicado: (2022)

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors
por: Schuller, Marion, et al.
Publicado: (2023)

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
por: Nguyen, My T., et al.
Publicado: (2021)

A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness
por: Katsonis, Panagiotis, et al.
Publicado: (2014)

CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation
por: Katsonis, Panagiotis, et al.
Publicado: (2019)

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases
por: Leung, Anthony K. L., et al.
Publicado: (2018)

13-(N,N-Dimethylamino)micheliolide 0.08-hydrate
por: Bommagani, Shobanbabu, et al.
Publicado: (2013)

(E)-13-(2-Bromophenyl)micheliolide
por: Penthala, Narsimha Reddy, et al.
Publicado: (2014)

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles
por: Longo, Michael A., et al.
Publicado: (2023)

Purification of NAD(+) glycohydrolase from human serum
por: COŞKUN, ÖZLEM, et al.
Publicado: (2013)

Oncogenic activity of poly (ADP-ribose) glycohydrolase
por: Marques, Maud, et al.
Publicado: (2018)

A new structural framework for integrating replication protein A into DNA processing machinery
por: Brosey, Chris A., et al.
Publicado: (2013)

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design
por: Zhang, Sixue, et al.
Publicado: (2021)

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis
por: Fehr, Anthony R., et al.
Publicado: (2018)

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
por: Alhammad, Yousef M. O., et al.
Publicado: (2020)

Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis
por: Zapata-Pérez, Rubén, et al.
Publicado: (2017)

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain
por: Ni, Xiaomin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i8dlb5krhv6s7h83eut05e5p78