Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

[Image: see text] A new class of pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles was synthesized for the treatment of hyperproliferative pathologies, including neoplasms. The new compounds were screened in the 60 human cancer cell lines of the NCI drug screen and showed potent activity with GI(50)...

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Detalles Bibliográficos
Autores principales: Spanò, Virginia, Rocca, Roberta, Barreca, Marilia, Giallombardo, Daniele, Montalbano, Alessandra, Carbone, Anna, Raimondi, Maria Valeria, Gaudio, Eugenio, Bortolozzi, Roberta, Bai, Ruoli, Tassone, Pierfrancesco, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Bertoni, Francesco, Barraja, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901646/
https://www.ncbi.nlm.nih.gov/pubmed/32986419
http://dx.doi.org/10.1021/acs.jmedchem.0c01315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901646/
https://www.ncbi.nlm.nih.gov/pubmed/32986419
http://dx.doi.org/10.1021/acs.jmedchem.0c01315

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