Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by another group. We review the anion CA inhibitors (...

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Detalles Bibliográficos
Autores principales: Nocentini, Alessio, Angeli, Andrea, Carta, Fabrizio, Winum, Jean-Yves, Zalubovskis, Raivis, Carradori, Simone, Capasso, Clemente, Donald, William A., Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901698/
https://www.ncbi.nlm.nih.gov/pubmed/33615947
http://dx.doi.org/10.1080/14756366.2021.1882453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901698/
https://www.ncbi.nlm.nih.gov/pubmed/33615947
http://dx.doi.org/10.1080/14756366.2021.1882453

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