Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

CD19‐directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B‐cell malignancies, specially in B‐cell acute lymphoblastic leukemia (B‐ALL). However, CAR T‐cell‐treated patients eventually progress due to poor CAR T‐cell persistence and/or disease re...

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Detalles Bibliográficos
Autores principales: Sánchez‐Martínez, Diego, Gutiérrez‐Agüera, Francisco, Romecin, Paola, Vinyoles, Meritxell, Palomo, Marta, Tirado, Néstor, Zanetti, Samanta Romina, Juan, Manel, Carlet, Michela, Jeremias, Irmela, Menéndez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901721/
https://www.ncbi.nlm.nih.gov/pubmed/33634970
http://dx.doi.org/10.1002/ctm2.280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901721/
https://www.ncbi.nlm.nih.gov/pubmed/33634970
http://dx.doi.org/10.1002/ctm2.280

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