Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

Loss of cellular homeostasis has been implicated in the etiology of several neurodegenerative diseases (NDs). However, the molecular mechanisms that underlie this loss remain poorly understood on a systems level in each case. Here, using a novel computational approach to integrate dimensional RNA-se...

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Detalles Bibliográficos
Autores principales: Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901871/
https://www.ncbi.nlm.nih.gov/pubmed/33618800
http://dx.doi.org/10.7554/eLife.64984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901871/
https://www.ncbi.nlm.nih.gov/pubmed/33618800
http://dx.doi.org/10.7554/eLife.64984

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