The Distinct Function of p21(Waf1/Cip1) With p16(Ink4a) in Modulating Aging Phenotypes of Werner Syndrome by Affecting Tissue Homeostasis

Human Werner syndrome (WS) is an autosomal recessive progeria disease. A mouse model of WS manifests the disease through telomere dysfunction-induced aging phenotypes, which might result from cell cycle control and cellular senescence. Both p21(Waf1/Cip1) (p21, encoded by the Cdkn1a gene) and p16(In...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yongjin, Shao, Chihao, Li, Haili, Wu, Kun, Gong, Lixin, Zheng, Quan, Dan, Juhua, Jia, Shuting, Tang, Xiaodan, Wu, Xiaoming, Luo, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901894/
https://www.ncbi.nlm.nih.gov/pubmed/33633779
http://dx.doi.org/10.3389/fgene.2021.597566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901894/
https://www.ncbi.nlm.nih.gov/pubmed/33633779
http://dx.doi.org/10.3389/fgene.2021.597566

Ejemplares similares