Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation

RTK-RAS-MAPK systems are major signaling pathways for cell fate decisions. Among the several RTK species, it is known that the transient activation of ERK (MAPK) stimulates cell proliferation, whereas its sustained activation induces cell differentiation. In both instances however, RAS activation is...

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Detalles Bibliográficos
Autores principales: Yoshizawa, Ryo, Umeki, Nobuhisa, Yamamoto, Akihiro, Murata, Masayuki, Sako, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan 2021
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902154/
https://www.ncbi.nlm.nih.gov/pubmed/33665062
http://dx.doi.org/10.2142/biophysico.bppb-v18.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902154/
https://www.ncbi.nlm.nih.gov/pubmed/33665062
http://dx.doi.org/10.2142/biophysico.bppb-v18.001

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