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Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation
RTK-RAS-MAPK systems are major signaling pathways for cell fate decisions. Among the several RTK species, it is known that the transient activation of ERK (MAPK) stimulates cell proliferation, whereas its sustained activation induces cell differentiation. In both instances however, RAS activation is...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society of Japan
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902154/ https://www.ncbi.nlm.nih.gov/pubmed/33665062 http://dx.doi.org/10.2142/biophysico.bppb-v18.001 |