Cargando…

Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no disease-modifying treatment. AD progression is characterized by cognitive decline, neuroinflammation, and accumulation of amyloid-beta (Aβ) and neurofibrillary tangles in the brain, leading to neuronal and glial dysfunction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lau, Jackie K. Y., Tian, Min, Shen, Yang, Lau, Shun-Fat, Fu, Wing-Yu, Fu, Amy K. Y., Ip, Nancy Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902646/ https://www.ncbi.nlm.nih.gov/pubmed/33623128 http://dx.doi.org/10.1038/s41598-021-83932-4

Ejemplares similares

Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
por: Lau, Shun-Fat, et al.
Publicado: (2021)

Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
por: Lau, Shun-Fat, et al.
Publicado: (2021)

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
por: Lau, Shun-Fat, et al.
Publicado: (2020)

The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
por: Lau, Shun-Fat, et al.
Publicado: (2023)

α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis
por: Su, Yi-Ting, et al.
Publicado: (2019)

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications
por: Zhou, Xiaopu, et al.
Publicado: (2021)

Venular amyloid accumulation in transgenic Fischer 344 Alzheimer’s disease rats
por: Bishay, J., et al.
Publicado: (2022)

An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease
por: Lau, Victor, et al.
Publicado: (2023)

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
por: Lee, Donghee, et al.
Publicado: (2023)

Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies
por: Getting, S. J., et al.
Publicado: (2009)

High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease
por: Bouvier, David S., et al.
Publicado: (2016)

New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis
por: Orellana, Juan A., et al.
Publicado: (2017)

S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength
por: Zhang, Peng, et al.
Publicado: (2015)

Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice
por: Jia, Y.L., et al.
Publicado: (2017)

Melanocortins, Melanocortin Receptors and Multiple Sclerosis
por: Lisak, Robert P., et al.
Publicado: (2017)

Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
por: Gaunt, Jessica R., et al.
Publicado: (2023)

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
por: Jiang, Yuanbing, et al.
Publicado: (2022)

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer’s disease mouse model
por: Dorostkar, Mario M., et al.
Publicado: (2014)

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
por: Paris, Daniel, et al.
Publicado: (2010)

Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice
por: Cruz, Nancy F, et al.
Publicado: (2010)

Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
por: Takeda, Keisuke, et al.
Publicado: (2021)

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation
por: Bao, Xiu-Qi, et al.
Publicado: (2013)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer’s disease model
por: Jeong, Jihoon, et al.
Publicado: (2020)

Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease
por: Weber-Adrian, Danielle, et al.
Publicado: (2019)

Ethanol Alleviates Amyloid-β-Induced Toxicity in an Alzheimer’s Disease Model of Caenorhabiditis elegans
por: Bai, Shuju, et al.
Publicado: (2021)

Demonstration of a Common DPhe(7) to DNal(2′)(7) Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides
por: Gimenez, Luis E., et al.
Publicado: (2022)

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling
por: Wang, Xiaozhu, et al.
Publicado: (2022)

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
por: Bellaver, Bruna, et al.
Publicado: (2023)

Rhinacanthin C Alleviates Amyloid-β Fibrils' Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells
por: Chuang, Kai-An, et al.
Publicado: (2017)

Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong
por: Wong, Hiu Yi, et al.
Publicado: (2022)

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

p35 Regulates the CRM1-Dependent Nucleocytoplasmic Shuttling of Nuclear Hormone Receptor Coregulator-Interacting Factor 1 (NIF-1)
por: Zhao, Xiao-Su, et al.
Publicado: (2014)

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease
por: Gao, Qiang, et al.
Publicado: (2019)

Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs
por: Gu, Shuo, et al.
Publicado: (2018)

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors
por: Michael, Natalie J., et al.
Publicado: (2020)

p39-associated Cdk5 activity regulates dendritic morphogenesis
por: Ouyang, Li, et al.
Publicado: (2020)

Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model
por: Boutajangout, Allal, et al.
Publicado: (2019)

Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist
por: Suzuki, T., et al.
Publicado: (2021)

Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex
por: Ye, Tao, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5s529dcvi51k7brnsj49t6nn2l