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A rotary mechanism for allostery in bacterial hybrid malic enzymes

Bacterial hybrid malic enzymes (MaeB grouping, multidomain) catalyse the transformation of malate to pyruvate, and are a major contributor to cellular reducing power and carbon flux. Distinct from other malic enzyme subtypes, the hybrid enzymes are regulated by acetyl-CoA, a molecular indicator of t...

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Detalles Bibliográficos
Autores principales: Harding, Christopher John, Cadby, Ian Thomas, Moynihan, Patrick Joseph, Lovering, Andrew Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902834/
https://www.ncbi.nlm.nih.gov/pubmed/33623032
http://dx.doi.org/10.1038/s41467-021-21528-2