Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins

Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (SOS). Oncogenic Ras mutations could affect the...

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Detalles Bibliográficos
Autores principales: Wang, Yuanhao, Ji, Dong, Lei, Chaoyu, Chen, Yingfei, Qiu, Yuran, Li, Xinyi, Li, Mingyu, Ni, Duan, Pu, Jun, Zhang, Jian, Fu, Qiang, Liu, Yaqin, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902900/
https://www.ncbi.nlm.nih.gov/pubmed/33680360
http://dx.doi.org/10.1016/j.csbj.2021.01.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902900/
https://www.ncbi.nlm.nih.gov/pubmed/33680360
http://dx.doi.org/10.1016/j.csbj.2021.01.044

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