Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

BACKGROUND: Accumulation of hyperphosphorylated tau (pTau) protein is associated with synaptic dysfunction in Alzheimer’s disease (AD). We previously demonstrated that neuroprotection in familial mouse models of AD could be achieved by targeting mitochondria complex I (MCI) and activating the adapti...

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Detalles Bibliográficos
Autores principales: Stojakovic, Andrea, Chang, Su-Youne, Nesbitt, Jarred, Pichurin, Nicholas P., Ostroot, Mark A., Aikawa, Tomonori, Kanekiyo, Takahisa, Trushina, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902954/
https://www.ncbi.nlm.nih.gov/pubmed/33285637
http://dx.doi.org/10.3233/JAD-201015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902954/
https://www.ncbi.nlm.nih.gov/pubmed/33285637
http://dx.doi.org/10.3233/JAD-201015

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