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APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid(1)

BACKGROUND: APOE4 has been hypothesized to increase Alzheimer’s disease risk by increasing neuroinflammation, though the specific neuroinflammatory pathways involved are unclear. OBJECTIVE: Characterize cerebrospinal fluid (CSF) proteomic changes related to APOE4 copy number. METHODS: We analyzed ta...

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Detalles Bibliográficos
Autores principales: Berger, Miles, Cooter, Mary, Roesler, Alexander S., Chung, Stacey, Park, John, Modliszewski, Jennifer L., VanDusen, Keith W., Thompson, J. Will, Moseley, Arthur, Devinney, Michael J., Smani, Shayan, Hall, Ashley, Cai, Victor, Browndyke, Jeffrey N., Lutz, Michael W., Corcoran, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902966/
https://www.ncbi.nlm.nih.gov/pubmed/33337362
http://dx.doi.org/10.3233/JAD-200747