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Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ(42)-Induced Pathways to Alzheimer’s Disease Pathology
BACKGROUND: The 42 amino acids long amyloid-β peptide, Aβ(42), may initiate a cascade of events leading to the severe neurodegeneration observed in Alzheimer’s disease (AD) brain. However, the underlying molecular mechanisms remain to be established. OBJECTIVE: To find early Aβ(42)-induced AD relate...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902969/ https://www.ncbi.nlm.nih.gov/pubmed/32280097 http://dx.doi.org/10.3233/JAD-200028 |