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Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ(42)-Induced Pathways to Alzheimer’s Disease Pathology

BACKGROUND: The 42 amino acids long amyloid-β peptide, Aβ(42), may initiate a cascade of events leading to the severe neurodegeneration observed in Alzheimer’s disease (AD) brain. However, the underlying molecular mechanisms remain to be established. OBJECTIVE: To find early Aβ(42)-induced AD relate...

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Detalles Bibliográficos
Autores principales:	Schedin-Weiss, Sophia, Nilsson, Per, Sandebring-Matton, Anna, Axenhus, Michael, Sekiguchi, Misaki, Saito, Takashi, Winblad, Bengt, Saido, Takaomi, Tjernberg, Lars O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902969/ https://www.ncbi.nlm.nih.gov/pubmed/32280097 http://dx.doi.org/10.3233/JAD-200028

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