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Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data

EEG-correlated fMRI analysis is widely used to detect regional BOLD fluctuations that are synchronized to interictal epileptic discharges, which can provide evidence for localizing the ictal onset zone. However, the typical, asymmetrical and mass-univariate approach cannot capture the inherent, high...

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Autores principales: Van Eyndhoven, Simon, Dupont, Patrick, Tousseyn, Simon, Vervliet, Nico, Van Paesschen, Wim, Van Huffel, Sabine, Hunyadi, Borbála
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903163/
https://www.ncbi.nlm.nih.gov/pubmed/33359347
http://dx.doi.org/10.1016/j.neuroimage.2020.117652
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author Van Eyndhoven, Simon
Dupont, Patrick
Tousseyn, Simon
Vervliet, Nico
Van Paesschen, Wim
Van Huffel, Sabine
Hunyadi, Borbála
author_facet Van Eyndhoven, Simon
Dupont, Patrick
Tousseyn, Simon
Vervliet, Nico
Van Paesschen, Wim
Van Huffel, Sabine
Hunyadi, Borbála
author_sort Van Eyndhoven, Simon
collection PubMed
description EEG-correlated fMRI analysis is widely used to detect regional BOLD fluctuations that are synchronized to interictal epileptic discharges, which can provide evidence for localizing the ictal onset zone. However, the typical, asymmetrical and mass-univariate approach cannot capture the inherent, higher order structure in the EEG data, nor multivariate relations in the fMRI data, and it is nontrivial to accurately handle varying neurovascular coupling over patients and brain regions. We aim to overcome these drawbacks in a data-driven manner by means of a novel structured matrix-tensor factorization: the single-subject EEG data (represented as a third-order spectrogram tensor) and fMRI data (represented as a spatiotemporal BOLD signal matrix) are jointly decomposed into a superposition of several sources, characterized by space-time-frequency profiles. In the shared temporal mode, Toeplitz-structured factors account for a spatially specific, neurovascular ‘bridge’ between the EEG and fMRI temporal fluctuations, capturing the hemodynamic response’s variability over brain regions. By analyzing interictal data from twelve patients, we show that the extracted source signatures provide a sensitive localization of the ictal onset zone (10/12). Moreover, complementary parts of the IOZ can be uncovered by inspecting those regions with the most deviant neurovascular coupling, as quantified by two entropy-like metrics of the hemodynamic response function waveforms (9/12). Hence, this multivariate, multimodal factorization provides two useful sets of EEG-fMRI biomarkers, which can assist the presurgical evaluation of epilepsy. We make all code required to perform the computations available at https://github.com/svaneynd/structured-cmtf.
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spelling pubmed-79031632021-03-03 Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data Van Eyndhoven, Simon Dupont, Patrick Tousseyn, Simon Vervliet, Nico Van Paesschen, Wim Van Huffel, Sabine Hunyadi, Borbála Neuroimage Article EEG-correlated fMRI analysis is widely used to detect regional BOLD fluctuations that are synchronized to interictal epileptic discharges, which can provide evidence for localizing the ictal onset zone. However, the typical, asymmetrical and mass-univariate approach cannot capture the inherent, higher order structure in the EEG data, nor multivariate relations in the fMRI data, and it is nontrivial to accurately handle varying neurovascular coupling over patients and brain regions. We aim to overcome these drawbacks in a data-driven manner by means of a novel structured matrix-tensor factorization: the single-subject EEG data (represented as a third-order spectrogram tensor) and fMRI data (represented as a spatiotemporal BOLD signal matrix) are jointly decomposed into a superposition of several sources, characterized by space-time-frequency profiles. In the shared temporal mode, Toeplitz-structured factors account for a spatially specific, neurovascular ‘bridge’ between the EEG and fMRI temporal fluctuations, capturing the hemodynamic response’s variability over brain regions. By analyzing interictal data from twelve patients, we show that the extracted source signatures provide a sensitive localization of the ictal onset zone (10/12). Moreover, complementary parts of the IOZ can be uncovered by inspecting those regions with the most deviant neurovascular coupling, as quantified by two entropy-like metrics of the hemodynamic response function waveforms (9/12). Hence, this multivariate, multimodal factorization provides two useful sets of EEG-fMRI biomarkers, which can assist the presurgical evaluation of epilepsy. We make all code required to perform the computations available at https://github.com/svaneynd/structured-cmtf. Academic Press 2021-03 /pmc/articles/PMC7903163/ /pubmed/33359347 http://dx.doi.org/10.1016/j.neuroimage.2020.117652 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Van Eyndhoven, Simon
Dupont, Patrick
Tousseyn, Simon
Vervliet, Nico
Van Paesschen, Wim
Van Huffel, Sabine
Hunyadi, Borbála
Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
title Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
title_full Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
title_fullStr Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
title_full_unstemmed Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
title_short Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
title_sort augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic eeg and fmri data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903163/
https://www.ncbi.nlm.nih.gov/pubmed/33359347
http://dx.doi.org/10.1016/j.neuroimage.2020.117652
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