Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

Woodchuck Hepatitis Virus Post-transcriptional Regulatory Element (WPRE) is thought to enhance transgene expression of target genes delivered by adeno-associated viral (AAV) vectors. This study assessed the protein expression of α-synuclein, phosphorylated α-synuclein at Serine 129, extent of nigros...

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Detalles Bibliográficos
Autores principales: Sun, Xiuping, Yu, Xuan, Zhang, Ling, Zhao, Wenjie, Wang, Manshi, Zhang, Yu, Li, Xianglei, Gao, Ran, Breger, Ludivine S., Dovero, Sandra, Porras, Gregory, Fernagut, Pierre-Olivier, Dehay, Benjamin, Bezard, Erwan, Qin, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903312/
https://www.ncbi.nlm.nih.gov/pubmed/33665452
http://dx.doi.org/10.1016/j.heliyon.2021.e06302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903312/
https://www.ncbi.nlm.nih.gov/pubmed/33665452
http://dx.doi.org/10.1016/j.heliyon.2021.e06302

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