Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis

BACKGROUND & AIMS: Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes. We examined the role of TGR5 in alcohol-induced liver injury in...

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Detalles Bibliográficos
Autores principales: Spatz, Madeleine, Ciocan, Dragos, Merlen, Gregory, Rainteau, Dominique, Humbert, Lydie, Gomes-Rochette, Neuza, Hugot, Cindy, Trainel, Nicolas, Mercier-Nomé, Françoise, Domenichini, Séverine, Puchois, Virginie, Wrzosek, Laura, Ferrere, Gladys, Tordjmann, Thierry, Perlemuter, Gabriel, Cassard, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903352/
https://www.ncbi.nlm.nih.gov/pubmed/33665587
http://dx.doi.org/10.1016/j.jhepr.2021.100230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903352/
https://www.ncbi.nlm.nih.gov/pubmed/33665587
http://dx.doi.org/10.1016/j.jhepr.2021.100230

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