Generation of glioblastoma patient-derived organoids and mouse brain orthotopic xenografts for drug screening

Robust patient-derived platforms that recapitulate the cellular and molecular fingerprints of glioblastoma are crucial for developing effective therapies. Here, we describe a chemically defined protocol for 3D culture and propagation of glioblastoma in 3D gliospheres, patient-derived organoids (PDOs...

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Detalles Bibliográficos
Autores principales: Gamboa, Christian Moya, Jara, Kelly, Pamarthy, Sahithi, Liu, Liqiong, Aiken, Robert, Xiong, Zhenggang, Danish, Shabbar, Sabaawy, Hatem E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903462/
https://www.ncbi.nlm.nih.gov/pubmed/33665625
http://dx.doi.org/10.1016/j.xpro.2021.100345