Hearing impairment due to Mir183/96/182 mutations suggests both loss-of-function and gain-of-function effects

The microRNA miR-96 is important for hearing, as point mutations in humans and mice result in dominant progressive hearing loss. Mir96 is expressed in sensory cells along with Mir182 and Mir183, but the roles of these closely-linked microRNAs are as yet unknown. Here, we analyse mice carrying null a...

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Detalles Bibliográficos
Autores principales: Lewis, Morag A., Di Domenico, Francesca, Ingham, Neil J., Prosser, Haydn M., Steel, Karen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903918/
https://www.ncbi.nlm.nih.gov/pubmed/33318051
http://dx.doi.org/10.1242/dmm.047225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903918/
https://www.ncbi.nlm.nih.gov/pubmed/33318051
http://dx.doi.org/10.1242/dmm.047225

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