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Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid β-protein
Epitope-specific enzymes are powerful tools for site-specific protein modification, but generally require genetic manipulation of the target protein. Here, we describe the laboratory evolution of the bacterial transpeptidase sortase A to recognize the LMVGG sequence in endogenous Aβ protein. Using a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904614/ https://www.ncbi.nlm.nih.gov/pubmed/33432237 http://dx.doi.org/10.1038/s41589-020-00706-1 |