Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway

Benzo[a]pyrene (BaP) is bioactivated in most organisms by the cytochrome P450 (CYP) enzymes, mainly CYP1A1, ultimately resulting in the reactive metabolite BaP-7,8-dihydrodiol-9,10-epoxide (BPDE) capable of covalently binding to DNA and forming adducts. This step has been defined as the key process...

Descripción completa

Detalles Bibliográficos
Autores principales: Abbass, Mustafa, Chen, Yuzhi, Arlt, Volker M., Stürzenbaum, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904753/
https://www.ncbi.nlm.nih.gov/pubmed/33420596
http://dx.doi.org/10.1007/s00204-020-02968-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904753/
https://www.ncbi.nlm.nih.gov/pubmed/33420596
http://dx.doi.org/10.1007/s00204-020-02968-z

Ejemplares similares