Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane

TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in promoting metastasis and chemoresistance. Previously, we uncovered a role for...

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Detalles Bibliográficos
Autores principales: Phatak, Vinaya, von Grabowiecki, Yannick, Janus, Justyna, Officer, Leah, Behan, Caron, Aschauer, Lydia, Pinon, Lucia, Mackay, Hannah, Zanivan, Sara, Norman, Jim C., Kelly, Michael, Le Quesne, John, Muller, Patricia A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904762/
https://www.ncbi.nlm.nih.gov/pubmed/33627632
http://dx.doi.org/10.1038/s41419-021-03497-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904762/
https://www.ncbi.nlm.nih.gov/pubmed/33627632
http://dx.doi.org/10.1038/s41419-021-03497-y

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