The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress

Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR). Previous biochemical studies have shown that Ire1 exhibits strong endoribonuclease activity when its cytosolic kin...

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Detalles Bibliográficos
Autores principales: Le, Quynh Giang, Ishiwata-Kimata, Yuki, Phuong, Thi Huong, Fukunaka, Shigeto, Kohno, Kenji, Kimata, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904763/
https://www.ncbi.nlm.nih.gov/pubmed/33627709
http://dx.doi.org/10.1038/s41598-021-83890-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904763/
https://www.ncbi.nlm.nih.gov/pubmed/33627709
http://dx.doi.org/10.1038/s41598-021-83890-x

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