Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an incurable neurodegenerative disorder caused by expansion of CGG repeats in the FMR1 5’UTR. The RNA containing expanded CGG repeats (rCGG(exp)) causes cell damage by interaction with complementary DNA, forming R-loop structures, sequestration...

Descripción completa

Detalles Bibliográficos
Autores principales: Derbis, Magdalena, Kul, Emre, Niewiadomska, Daria, Sekrecki, Michał, Piasecka, Agnieszka, Taylor, Katarzyna, Hukema, Renate K., Stork, Oliver, Sobczak, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904788/
https://www.ncbi.nlm.nih.gov/pubmed/33627639
http://dx.doi.org/10.1038/s41467-021-21021-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904788/
https://www.ncbi.nlm.nih.gov/pubmed/33627639
http://dx.doi.org/10.1038/s41467-021-21021-w

Ejemplares similares