Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation

The prevalence and dire implications of mutations in the tumour suppressor, p53, highlight its appeal as a chemotherapeutic target. We recently showed that impairing cellular antioxidant systems via inhibition of SLC7A11, a component of the system x(c)(−) cystine-glutamate antiporter, enhances sensi...

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Detalles Bibliográficos
Autores principales: Milne, Julia V., Zhang, Bonnie Z., Fujihara, Kenji M., Dawar, Swati, Phillips, Wayne A., Clemons, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904805/
https://www.ncbi.nlm.nih.gov/pubmed/33627789
http://dx.doi.org/10.1038/s41598-021-83979-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904805/
https://www.ncbi.nlm.nih.gov/pubmed/33627789
http://dx.doi.org/10.1038/s41598-021-83979-3

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