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Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation
The prevalence and dire implications of mutations in the tumour suppressor, p53, highlight its appeal as a chemotherapeutic target. We recently showed that impairing cellular antioxidant systems via inhibition of SLC7A11, a component of the system x(c)(−) cystine-glutamate antiporter, enhances sensi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904805/ https://www.ncbi.nlm.nih.gov/pubmed/33627789 http://dx.doi.org/10.1038/s41598-021-83979-3 |