Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine

Subanesthetic ketamine evokes rapid antidepressant effects in human patients that persist long past ketamine’s chemical half-life of ~2 h. Ketamine’s sustained antidepressant action may be due to modulation of cortical plasticity. We find that ketamine ameliorates depression-like behavior in the for...

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Detalles Bibliográficos
Autores principales: Grieco, Steven F., Qiao, Xin, Johnston, Kevin G., Chen, Lujia, Nelson, Renetta R., Lai, Cary, Holmes, Todd C., Xu, Xiangmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904825/
https://www.ncbi.nlm.nih.gov/pubmed/33627623
http://dx.doi.org/10.1038/s41398-021-01255-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904825/
https://www.ncbi.nlm.nih.gov/pubmed/33627623
http://dx.doi.org/10.1038/s41398-021-01255-4

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