Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

DNA methylation (5mC) is central to cellular identity. The global erasure of 5mC from the parental genomes during preimplantation mammalian development is critical to reset the methylome of gametes to the cells in the blastocyst. While active and passive modes of demethylation have both been suggest...

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Detalles Bibliográficos
Autores principales: Sen, Maya, Mooijman, Dylan, Chialastri, Alex, Boisset, Jean-Charles, Popovic, Mina, Heindryckx, Björn, Chuva de Sousa Lopes, Susana M., Dey, Siddharth S., van Oudenaarden, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904860/
https://www.ncbi.nlm.nih.gov/pubmed/33627650
http://dx.doi.org/10.1038/s41467-021-21532-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904860/
https://www.ncbi.nlm.nih.gov/pubmed/33627650
http://dx.doi.org/10.1038/s41467-021-21532-6

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