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Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
DNA methylation (5mC) is central to cellular identity. The global erasure of 5mC from the parental genomes during preimplantation mammalian development is critical to reset the methylome of gametes to the cells in the blastocyst. While active and passive modes of demethylation have both been suggest...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904860/ https://www.ncbi.nlm.nih.gov/pubmed/33627650 http://dx.doi.org/10.1038/s41467-021-21532-6 |