Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability

BACKGROUND: The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing conserved roles in regulating cell behavior, brain development and morphogenesis...

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Detalles Bibliográficos
Autores principales: Rogers, Edward M., Allred, S. Colby, Peifer, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905622/
https://www.ncbi.nlm.nih.gov/pubmed/33627133
http://dx.doi.org/10.1186/s12964-020-00703-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905622/
https://www.ncbi.nlm.nih.gov/pubmed/33627133
http://dx.doi.org/10.1186/s12964-020-00703-w

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