Cargando…
Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability
BACKGROUND: The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing conserved roles in regulating cell behavior, brain development and morphogenesis...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905622/ https://www.ncbi.nlm.nih.gov/pubmed/33627133 http://dx.doi.org/10.1186/s12964-020-00703-w |