Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

BACKGROUND: KRAS is the most frequently mutated oncogene in cancer, however efforts to develop targeted therapies have been largely unsuccessful. Recently, two small-molecule inhibitors, AMG 510 and MRTX849, have shown promising activity in KRAS G12C-mutant solid tumors. The current study aims to as...

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Detalles Bibliográficos
Autores principales: Araujo, Luiz Henrique, Souza, Bianca Mendes, Leite, Laura Rabelo, Parma, Sabrina A. F., Lopes, Natália P., Malta, Frederico S. V., Freire, Maíra C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905642/
https://www.ncbi.nlm.nih.gov/pubmed/33632153
http://dx.doi.org/10.1186/s12885-021-07884-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905642/
https://www.ncbi.nlm.nih.gov/pubmed/33632153
http://dx.doi.org/10.1186/s12885-021-07884-8

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