Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploin...

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Detalles Bibliográficos
Autores principales: Hurley, Shaun, Mohan, Conor, Suetterlin, Philipp, Ellingford, Robert, Riegman, Kimberley L. H., Ellegood, Jacob, Caruso, Angela, Michetti, Caterina, Brock, Olivier, Evans, Romy, Rudari, Fabrizio, Delogu, Alessio, Scattoni, Maria Luisa, Lerch, Jason P., Fernandes, Cathy, Basson, M. Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905672/
https://www.ncbi.nlm.nih.gov/pubmed/33627187
http://dx.doi.org/10.1186/s13229-020-00409-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905672/
https://www.ncbi.nlm.nih.gov/pubmed/33627187
http://dx.doi.org/10.1186/s13229-020-00409-3

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