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Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis

OBJECTIVE: To evaluate trials of drugs that target amyloid to determine whether reductions in amyloid levels are likely to improve cognition. DESIGN: Instrumental variable meta-analysis. SETTING: 14 randomized controlled trials of drugs for the prevention or treatment of Alzheimer’s disease that tar...

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Detalles Bibliográficos
Autores principales: Ackley, Sarah F, Zimmerman, Scott C, Brenowitz, Willa D, Tchetgen Tchetgen, Eric J, Gold, Audra L, Manly, Jennifer J, Mayeda, Elizabeth Rose, Filshtein, Teresa J, Power, Melinda C, Elahi, Fanny M, Brickman, Adam M, Glymour, M Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905687/
https://www.ncbi.nlm.nih.gov/pubmed/33632704
http://dx.doi.org/10.1136/bmj.n156