Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms

Stable atherosclerotic plaques are characterized by a thick extracellular matrix (ECM)-rich fibrous cap populated by protective ACTA2(+) myofibroblast (MF)-like cells, assumed to be almost exclusively derived from smooth muscle cells (SMC). Herein, we show that in murine and human lesions, 20 to 40%...

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Detalles Bibliográficos
Autores principales: Newman, Alexandra AC, Serbulea, Vlad, Baylis, Richard A, Shankman, Laura S, Bradley, Xenia, Alencar, Gabriel F, Owsiany, Katherine, Deaton, Rebecca A, Karnewar, Santosh, Shamsuzzaman, Sohel, Salamon, Anita, Reddy, Mahima S, Guo, Liang, Finn, Aloke, Virmani, Renu, Cherepanova, Olga A, Owens, Gary K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905710/
https://www.ncbi.nlm.nih.gov/pubmed/33619382
http://dx.doi.org/10.1038/s42255-020-00338-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905710/
https://www.ncbi.nlm.nih.gov/pubmed/33619382
http://dx.doi.org/10.1038/s42255-020-00338-8

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