Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation

[Image: see text] Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides (9a–m and 10a–m) were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhibitory activity and cytotoxi...

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Detalles Bibliográficos
Autores principales: Anh, Duong T., Hai, Pham-The, Huy, Le D., Ngoc, Hoang B., Ngoc, Trinh T. M., Dung, Do T. M., Park, Eun J., Song, In K., Kang, Jong S., Kwon, Joo-Hee, Tung, Truong T., Han, Sang-Bae, Nam, Nguyen-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905942/
https://www.ncbi.nlm.nih.gov/pubmed/33644598
http://dx.doi.org/10.1021/acsomega.0c05870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905942/
https://www.ncbi.nlm.nih.gov/pubmed/33644598
http://dx.doi.org/10.1021/acsomega.0c05870

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